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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Acta Biomater. 2012 Feb 8;8(5):1685–1692. doi: 10.1016/j.actbio.2012.01.036

Figure 6.

Figure 6

Insulinotropic activity of PA gels. The 8mM PA gels containing 5000 RINm5f cells/uL were assayed for stimulation of insulin release at 24 hours in the presence or absence of inflammatory cytokines (20ng/mL IL-1β, 40ng/mL TNF-α, and 100ng/mL IFN-γ) to demonstrate that GLP-1-mimetic PA gel at 10% or 100% produces significantly higher insulin release than exendin-4 or control PA gel (a; error bars: 95%CI; ** p<0.01 vs. control PA gel; ## p<0.01 vs. exendin-4 in control PA gel). The time course and dose response of insulin release from GLP-1-mimetic PA gels are shown (b; error bars: 95%CI; ** p<0.01 vs. control PA gel at 4 hours; ## p<0.01 vs. control PA gel at 24 hours).