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Effect of pretreatment with 3.2 mg/kg VU0357017, an M1-selective partial agonist, on the cocaine dose-effect function in wild-type, M1−/− and M4−/− mice. Abscissae: dose cocaine in mg/kg, “Sal” indicates saline. Ordinates: percentage cocaine-appropriate responses (top); response rate in responses per second (bottom). Data are groups means ± one S.E.M. Group sizes: N=6–8.
