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Summary of putative pathophysiologic mechanisms in the development of hypertension in diabetes mellitus. RAAS—renin-angiotensin-aldosterone system; SNS—sympathetic nervous system; VSMC—vascular smooth muscle cell. (From Mugo MN, Stump CS, Rao PG, Sowers JR. Chapter 34: Hypertension and Diabetes Mellitus. Hypertension: A Companion to Braunwald’s Heart Disease. Copyright Elsevier, 2007 [113])
