Table 3. Association between mother-to-child transmission of HIV and antiretroviral regimens taken in pregnancy, KwaZulu-Natal, South Africa, 2008–2009 (n = 2858) .
| Regimena | Infants with anti-HIV antibodiesb |
OR | 95% CI | P | ||
|---|---|---|---|---|---|---|
| No. tested by PCR | Found PCR-positive for HIV DNA |
|||||
| No. | % | |||||
| No antiretroviral prophylaxisc | 68 | 11 | 16.2 | – | – | – |
| Nevirapine alone | 242 | 32 | 13.2 | 0.78 | 0.32–1.9 | 0.58 |
| Zidovudine alone | 63 | 2 | 3.2 | 0.17 | 0.04–0.78 | 0.02 |
| Nevirapine and zidovudine | 2089 | 118 | 5.7 | 0.30 | 0.14–0.66 | 0.003 |
| Lifelong ART | 396 | 20 | 5.1 | 0.27 | 0.11–0.68 | 0.006 |
ART, antiretroviral treatment; CI, confidence interval; DNA, desoxyribonucleic acid; HIV, human immunodeficiency virus; OR, odds ratio; PCR, polymerase chain reaction.
a Mothers were allocated to regimen groups irrespective of the reported duration of each antiretroviral intervention.
b The infants tested were aged 4–8 weeks.
c Reference category.