Table 1.
Conditions associated with marked peripheral blood eosinophilia
| Infectious Diseases |
| Parasitic infections primarily with helminths (see Table 2) |
| Certain fungal infections (Allergic bronchopulmonary aspergillosis, Coccidiomycosis) |
| Infestations – Scabies, Myiasis |
| Allergic or Atopic Diseases |
| Drug hypersensitivity or medication-associated eosinophilias |
| Atopic diseases |
| Hematologic and Neoplastic Disorders |
| Hypereosinophilic syndromes (HES) including chronic eosinophilic leukemia |
| Leukemia (Acute myelogenous leukemias most commonly, B cell ALL) |
| Lymphomas (particularly Hodgkin’s, T- and B-cell lymphomas) |
| Tumor associated |
| Adenocarcinomas |
| Squamous carcinomas |
| Large cell lung carcinomas |
| Transitional cell carcinoma of the bladder |
| Systemic mastocytosis |
| Immunologic |
| Primary Immunodeficiency Diseases (HyperIgE syndrome, Omenn’s syndrome, Dock8 deficiency, IPEX, Zap70 deficiency) |
| Graft-versus-host-Disease |
| Endocrinologic Disorders |
| Hypoadrenalism |
| Other |
| Irradiation |
| Atheroembolic Disorders |
| Sarcoidosis |