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. Author manuscript; available in PMC: 2013 Mar 22.
Published in final edited form as: Neuron. 2012 Mar 21;73(6):1100–1107. doi: 10.1016/j.neuron.2012.01.020

Figure 1.

Figure 1

KbDb KO mice recover better than WT cohorts following MCAO. (A) Top: Example of sections of Cresyl Violet stained brains 7d post MCAO. Bottom: KO animals have significantly smaller infarct areas at 7d (p=0.03), but not 24hr (p=0.45), post MCAO. (B, C) KO animals outperform WT cohorts on motor tasks post MCAO. Average Rotarod (B) and Foot Fault (C) performances were assessed on days 2 and 7 post MCAO in all animals, and cohorts of each genotype were kept through 1 month survival with additional testing on days 14, 21 and 28. P values for the comparisons between genotypes on Rotarod on days 21 and 28 were 0.056 and 0.057 respectively, reflecting the reduced numbers of surviving animals. Groups were 19–25 mice (days 2 and 7), and 7–10 mice (days 14–28). P<0.05 refers to A–C. Data are represented as mean +/− SEM. See also Figure S1.