. 2011 Mar 9;32(6):888–896. doi: 10.1093/carcin/bgr045

Table I.

Effects of pomegranate treatment on the development and growth of macroscopic hepatocyte nodules induced by DENA-PB in rats

Groups	Rats with nodules/total rats	Nodule incidence (%)	Total no. of nodules	Average no. of nodules/nodule-bearing liver (nodule multiplicity)	Nodules relative to size (% of total no.)			Mean nodular volume^a (cm³)	Nodular volume/liver volume^b (%)
Groups	Rats with nodules/total rats	Nodule incidence (%)	Total no. of nodules		≥3 mm	<3 to >1 mm	≤1 mm	Mean nodular volume^a (cm³)	Nodular volume/liver volume^b (%)
B—Sham + DENA	11/12	92	199	18.1 ± 1.4^c	46 ± 2	27 ± 2	27 ± 2	0.10 ± 0.01	0.52 ± 0.04
C—Pomegranate (1 g/kg) + DENA	8/12	66	112	14.0 ± 0.7^e	37 ± 4^g	31 ± 3	32 ± 3	0.08 ± 0.00^g	0.39 ± 0.04
D—Pomegranate (10 g/kg) + DENA	5/12	42^d	56	11.2 ± 0.7^f	30 ± 3^e	35 ± 2	35 ± 4	0.06 ± 0.00^e	0.40 ± 0.05

Animals from normal (Group A) and pomegranate (10 g/kg) control group (Group E) did not show any visible hepatocyte nodule.

Individual nodule volume was calculated from two perpendicular diameters on each nodule. For details, please see Material and Methods.

One gram of liver was assumed to occupy 1 cm³ for this calculation.

Values are presented as means ± SEMs.

^dP < 0.05 compared with Group B by Fisher’s exact probability test. ^eP < 0.01, ^fP < 0.001 and ^gP < 0.05 compared with Group B.