Table III.
Association of hTERT MNS16A genotypes and CRC risk
| MNS16A | CRC |
CRC + high-risk polyp |
CRC + high-risk + low-risk polyp |
|||||||
| Controls | Cases |
Cases |
Cases |
|||||||
| Alleles | N = 3424, N (%) | N = 176, N (%) | OR (95% CI)a | P value | N = 752, N (%) | OR (95% CI)a | P value | N = 2692, N (%) | OR (95% CI)a | P value |
| 302 | 2235 (65.27) | 113 (64.20) | 1.00 | 502 (66.76) | 1.00 | 1759 (65.34) | ||||
| 243 | 1082 (31.60) | 54 (30.68) | 0.96 (0.69–1.35) | 0.825 | 218 (28.99) | 0.88 (0.74–1.05) | 0.160 | 834 (30.98) | 0.96 (0.86–1.08) | 0.510 |
| 274 | 55 (1.61) | 6 (3.41) | 2.69 (1.11–6.50) | 0.028 | 15 (1.99) | 1.29 (0.71–2.33) | 0.400 | 48 (1.78) | 1.13 (0.76–1.69) | 0.546 |
| 333 | 52 (1.52) | 3 (1.70) | 1.33 (0.40–4.45) | 0.640 | 17 (2.26) | 1.62 (0.92–2.87) | 0.098 | 51 (1.89) | 1.31 (0.88–1.96) | 0.185 |
| Genotypes | N = 1712, N (%) | N = 88, N (%) | N = 376, N (%) | N = 1346, N (%) | ||||||
| 302/302 | 734 (42.87) | 35 (39.77) | 1.00 | 162 (43.09) | 1.00 | 573 (42.57) | 1.00 | |||
| 243/243 | 180 (10.51) | 6 (6.82) | 0.68 (0.28–1.66) | 0.394 | 28 (7.45) | 0.68 (0.44–1.06) | 0.090 | 125 (9.29) | 0.85 (0.66–1.11) | 0.236 |
| 243/302 | 691 (40.36) | 38 (43.18) | 1.09 (0.68–1.77) | 0.713 | 154 (40.96) | 0.98 (0.76–1.25) | 0.846 | 549 (40.79) | 1.00 (0.85–1.17) | 0.968 |
| 302/333 | 36 (2.10) | 1 (1.14) | 0.66 (0.09–5.09) | 0.690 | 12 (3.19) | 1.62 (0.81–3.24) | 0.175 | 32 (2.38) | 1.19 (0.72–1.96) | 0.509 |
| 243/274 | 15 (0.88) | 2 (2.27) | 3.97 (0.84–18.77) | 0.082 | 3 (0.80) | 1.00 (0.28–3.61) | 0.995 | 16 (1.19) | 1.52 (0.73–3.16) | 0.265 |
| 274/302 | 40 (2.34) | 4 (4.55) | 2.48 (0.82–7.52) | 0.108 | 12 (3.19) | 1.41 (0.71–2.78) | 0.327 | 32 (2.38) | 1.00 (0.61–1.63) | 0.997 |
| 243/333 | 16 (0.93) | 2 (2.27) | 3.12 (0.65–14.94) | 0.154 | 5 (1.33) | 1.68 (0.60–4.76) | 0.326 | 19 (1.41) | 1.61 (0.81–3.20) | 0.177 |
| SL system | N = 1712, N (%) | N = 88, N (%) | N = 376, N (%) | N = 1346, N (%) | ||||||
| LL | 770 (44.98) | 36 (40.91) | 1.00 | 174 (46.28) | 1.00 | 605 (44.95) | 1.00 | |||
| SL | 747 (43.63) | 44 (50.00) | 1.21 (0.76–1.92) | 0.417 | 171 (45.48) | 0.98 (0.78–1.25) | 0.901 | 600 (44.58) | 1.00 (0.86–1.17) | 0.985 |
| SS | 195 (11.39) | 8 (9.09) | 0.87 (0.39–1.93) | 0.735 | 31 (8.24) | 0.69 (0.45–1.05) | 0.080 | 141 (10.48) | 0.89 (0.70–1.15) | 0.378 |
P values <0.05 were considered statistically significant (bold).
a
OR were adjusted for age, sex, smoking status and education.