Figure 2.

Inhibition mediated by GABA_B receptors does not significantly shape Purkinje cell response patterns. A, Sample pseudocolor sagittal ΔFR maps of the same Purkinje cell with inhibition intact (left), with only GABA_B receptors blocked (middle), and with both GABA_B and GABA_A receptors blocked (right). The baseline firing rates of this cell in the three conditions were 48, 48, and 53 spikes/s, respectively. The gray areas represent dendritic sites where glutamate photolysis directly targeted the recorded Purkinje cell. The white pixels represent sites in which no data was obtained due to stimulation failures or noise. B, Average vertically collapsed profiles of Purkinje cell responses to glutamate photorelease in the granule cell layer with inhibition intact (open black triangles), with only GABA_B receptors blocked (open burgundy triangles), and with both GABA_B and GABA_A receptors blocked (closed black triangles). The average change in firing rate from baseline from five cells is plotted as a function of lateral distance from the soma of the recorded Purkinje cell. Area plots showing the differences in change in firing rate between conditions are superimposed.