Table 2.
Different 5-aminosalicylic acid delivery systems, formulations and sites of 5-aminosalicylic acid release.
| Trade name | Standard dose | Delivery method | Site of 5-ASA release† | Formulation |
|---|---|---|---|---|
| Mesalamine, Asacol®, Ipocol® | 2.4–4.8 g | pH-dependent; soluble at pH ≥ 7 | Terminal ileum, colon | Coated with Eudragit® S resin |
| Claversal®, Salofalk® | 1.5–3 g/day | pH-dependent; soluble at pH ≥ 6 | Jejunum, ileum, colon | Coated with Eudragit® L resin |
| Pentasa® | 4 g | Delayed release through ethylcellulose coat | Duodenum, jejunum, ileum, colon | Microgranules coated in semi-permeable ethylcellulose |
| Lialda® | 2.4–4.8 g | pH-dependent; soluble at pH >7 | Terminal ileum, colon | Multi Matrix System matrices |
| Apriso® | 1.5 g | pH-dependent; soluble at pH ≥ 6 | Colon | Eudragit L-coated granules containing polymer matrix |