Table 2.

Talairach Coordinates and Voxelwise Analysis Results of Fractional Anisotropy, Radial Diffusivity (λ_⊥), and Trace (D_tr) Parameters of Heavy Cannabis Users (n=14) Relative to Normal Controls (n=14)

Changes in Diffusion Parameters	Anatomical Location	Cluster Size (# of Connected Voxels)	X	Y	Z
Fractional Anisotropy
	Right Posterior Internal Capsule	302	10	−18	−4
	Left Posterior Internal Capsule	687	−15	−18	−2
	Left Middle Temporal Gyrus	176	−44	−47	4
	Right Superior Temporal Gyrus	166	39	−33	11
Radial Diffusivity
	Left Middle Temporal	1714	−43	−40	−1
	Left Posterior Internal Capsule	1207	−23	−14	6
	Right Superior Temporal Gyrus	362	41	−32	6
	Right posterior Internal Capsule	774	28	−10	14
Trace
	Left Middle Temporal	1031	−44	−11	−12
	Left Middle Temporal	843	−42	−44	−2
	Rt Superior Temporal	431	40	−30	4
	Lt. posterior Internal capsule	488	−25	−13	10
Axial Diffusivity
	Lt Posterior Internal capsule	734	−16	−14	−3
	Rt posterior Internal Capsule	358	25	−17	6
	Rt superior temporal gyrus	588	36	−41	10