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. 2012 Mar 14;61(4):857–865. doi: 10.2337/db11-1113

FIG. 1.

FIG. 1.

Cα knockout NOD mice retrogenic for α-chains containing TRAV5D-4 but not non–TRAV5D-4 develop anti-insulin autoimmunity. Levels of IAA in mice retrogenic for TCR α-chains with TRAV5D-4 (A–G) or with non–TRAV5D-4 (H–M) and in female NOD/Bdc mice (N). The α-chain sequences are derived from NOD CD4 T-cell clones (A: 12–4.4 [n = 8]; B: 12–4.1 [n = 6]; C: 8–1.1 [n = 5]; D: BDC-6.9 [n = 4]; E: NY4.1 [n = 9]; F: 14H4 [n = 5]; G: 5F2 [n = 5]; H: 2H6 [n = 7]; I: 12–2.35 [n = 7]; J: 12–1.19 [n = 8]; K: BDC-10.1 [n = 7]; L: BDC-2.5 [n = 7]; M: 6C5 [n = 4]). Symbols represent individual mice, and each panel represents a different retrogenic strain with a unique N and TRAJ region. IAA index ≥0.01 is defined as positive.