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. 2012 Mar 14;61(4):857–865. doi: 10.2337/db11-1113

FIG. 6.

FIG. 6.

Retrogenic mice expressing chimeric human TRAV13–1 α-chains. Development of insulin autoantibodies (A) and diabetes incidence (B) of retrogenic mice expressing chimeric 12–4.1 and 8–1.1 α-chains for which Vα sequences were replaced with human TRAV13–1. Data of female wild-type NOD/Bdc mice are included for comparison. A: Chimeric retrogenic mice expressing human TRAV13–1 α-chains developed insulin autoantibodies. Symbols represent the peak values of insulin autoantibodies of individual mice (8–1.1: n = 8; 12–4.1: n = 8; NOD/Bdc: n = 5). IAA index ≥0.01 is defined as positive. B: Chimeric retrogenic mice (8–1.1: squares [n = 4]; 12–4.1 [n = 4]: triangles) developed diabetes.