Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Mar 14;61(4):761–772. doi: 10.2337/db11-1423

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

PMC Copyright notice

FIG. 7. — A: Neuronal densities in CA1–CA4 in hippocampi from control, BB/Wor, and C-peptide–replaced BB/Wor rats (n = 4 per group). In CA1 and CA2 of BB/Wor rats, neuronal densities were significantly decreased compared with controls. C-peptide replacement resulted in a significant protection against neuronal loss in CA1. No significant differences were seen for the groups in CA3 and CA4. *P < 0.05 vs. BB/Wor rats. Data are from Ref. 74. B: The protein expression of Bax in hippocampi in four individual animals per group. Bax was significantly increased in BB/Wor rats. C-peptide replacement significantly (*P < 0.05 vs. untreated BB/Wor rats) prevented this increase. Data are from Ref. 74. C: Expression of hippocampal presynaptic synaptophysin was significantly decreased in 4-month diabetic rats and was prevented by C-peptide replacement from onset of diabetes (***P < 0.001 vs. untreated BB/Wor rats). Data are from Ref. 10.