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K562 cell survival after BG and BCNU treatment. K562 cells retrovirally transduced with MGMT-2 (□), MGMT-3 (⋄), MGMT-5 (○), MGMT-11 (▵), or wt MGMT (▿) were treated with 25 μM BG plus 0–80 μM BCNU in A. Data represent the mean of four experiments. Retrovirally transduced K562 cells were treated with 0–800 μM BG plus 20 μM BCNU in B. There was 90–100% survival of transduced K562 cells at 0 μM BG plus 20 μM BCNU. Data represent the mean of four experiments (bars = SEM).
