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. Author manuscript; available in PMC: 2012 Mar 28.
Published in final edited form as: Future Virol. 2010 Jan;5(1):65–83. doi: 10.2217/fvl.09.69

Figure 1. Domain structure of the herpesvirus lytic origin-binding proteins.

Figure 1

Although herpesvirus lytic origin-binding proteins are quite diverse, there are a few limited similarities. HSV UL9 and CMV UL84 share DExD/H box similarities, and most of these proteins contain leucine zipper or pseudo zipper domains (blue and purple boxes). Many of these regions bind to the cellular protein C/EBP-α (also shown).

CMV: Cytomegalovirus; EBV: Epstein–Barr virus; HSV: Herpes simplex virus; KSHV: Kaposi’s sarcoma-associated herpesvirus.