Skip to main content
. Author manuscript; available in PMC: 2012 Mar 28.
Published in final edited form as: Future Virol. 2010 Jan;5(1):65–83. doi: 10.2217/fvl.09.69

Figure 4. Hypothetical model of common structures formed by herpesvirus origins.

Figure 4

EBV, KSHV and HSV OriS are envisioned to form higher-order structures that include inverted repeat hairpins that bind viral (UL9, Zta) or cellular (C/EBP-α) proteins. Transcription complexes formed at both ends of OriLyts are envisioned to induce topological changes that promote DNA unwinding and templates suitable for viral DNA replisomes to assemble.

EBV: Epstein–Barr virus; HSV: Herpes simplex virus; KSHV: Kaposi’s sarcoma-associated herpesvirus; OriS: Repeated short-region origin of replication.