. 2012 Apr;76(2):99–108.

Table I.

Mean ± standard deviation cardiovascular variables from 6 anesthetized dogs with 3% end-tidal isoflurane (ETI) to decrease arterial blood pressure (ABP) and cardiac index (CI) and treated for 1 h with 1 mL/kg body weight per min of an isotonic solution while at 3% ETI for the first 45 min and then lowered towards 1.6% ETI for the last 15 min of treatment

Variables	Baseline (1.0 MAC)	Deep anesthesia (2.3 MAC)	Fluid therapy

			10 min (2.3 MAC)	30 min (2.3 MAC)	60 min (1.2 MAC)
ETI (%)	1.3 ± 0.1^a	3.0 ± 0.2^b	3.0 ± 0.2^b	3.0 ± 0.2^b	1.6 ± 0.1^c
Temperature (°C)	37.4 ± 0.6^a,b	37.5 ± 0.4^a	37.4 ± 0.6^a,b	37.1 ± 0.5^b,c	36.9 ± 0.3^c
Heart rate (beats/min)	98 ± 17^a	103 ± 12^a,c	110 ± 8^a	111 ± 9^a	122 ± 16^b,c
CI (mL/kg per minute)	159 ± 34.6^a	96 ± 31.2^b	106 ± 23.6^b	123 ± 46.5^b	239 ± 73.8^c
SVI (mL/beat per kilogram)	1.6 ± 0.4^a	0.9 ± 0.2^b	1.0 ± 0.2^b	1.1 ± 0.4^b	1.9 ± 0.4^a
Δ SVI (%)	ND	ND	11^a	22^b	111^c
SVV (%)	9.3 ± 2.2^a	17.5 ± 3.4^b	11.8 ± 2.8^a,d	12.8 ± 4.1^a,d	5.7 ± 1.2^c
Δ SVV (%)	ND	ND	33^a	27^a	67^b
Systolic ABP (mmHg)	125 ± 18^a	71 ± 13^b	74 ± 2^b	70 ± 15^b	105 ± 30^a
Diastolic ABP (mmHg)	64 ± 16^a	39 ± 6^b	41 ± 9^b,c	37 ± 5^b	52 ± 13^a,c
Mean ABP (mmHg)	79 ± 15^a	47 ± 6^b	49 ± 11^b	46 ± 7^b	69 ± 15^a
SVRI (dynes · s/cm⁵ per kilogram)	76 ± 25^a	69 ± 32^a	58 ± 25^a,b	47 ± 26^b	42 ± 28^b
CVP (mmHg)	9.0 ± 2^a	12 ± 3^b	14 ± 3^c	16 ± 2^d	15 ± 3^c,d
Urine output (mL/kg)	1.3 ± 0.06^a	0.06 ± 0.09^b	0.05 ± 0.05^b	0.27 ± 0.22^b	2.1 ± 0.7^c

^a,b,c,d

Different superscript letters within a row indicate significant (P < 0.05) differences between values in that row.

MAC — Minimum alveolar concentration; ETI — End-tidal isoflurane; CI — Cardiac index; SVI — Stroke volume index; Δ SVI — Change in stroke volume index; ND — Not determined; SVV — Stroke volume variation; Δ SVV — Change in stroke volume variation; ABP — Arterial blood pressure; SVRI — Systemic vascular resistance index; CVP — Central-venous pressure.