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. 2012 Apr 2;122(4):1172–1179. doi: 10.1172/JCI58648

Figure 3. Comparison of the BBB and BCSFB.

Figure 3

Brain barriers are made up of the endothelial BBB and the epithelial BCSFB. (A) The BBB has two protective layers, the endothelium with tight junctions and the glia limitans, made up of parenchymal basement membrane and astrocyte foot processes. (B) In contrast to the CNS parenchyma, microvessels in the choroid plexus are fenestrated, allowing free diffusion between the blood and CSF. The BCSFB is made up of the choroid epithelial cells with their unique tight junctions.