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. 2012 Mar 26;122(4):1541–1552. doi: 10.1172/JCI58765

Figure 5. Enhanced DNA damage and checkpoint bypass in p53-deficient TNBC treated with combination therapy.

Figure 5

Mice harboring WU-BC3 and WU-BC5 TNBC were treated as indicated, and tumors were stained for γH2AX (A) and phosphohistone H3 (C). Original magnification, ×400 (A); ×200 (C). Representative IHC images are shown in A and C; quantitation ± 95% CIs are shown in B and D. Statistics were obtained by the Wilson score method in SPSS 20. ***P < 0.001.