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. 2012 Mar 26;122(4):1541–1552. doi: 10.1172/JCI58765

Figure 6. Effect of combination therapy on tumor growth and host survival.

Figure 6

Tumor-bearing NOD/SCID mice were randomly assigned to the indicated treatment groups (vehicle, irinotecan, AZD7762, or the combination of irinotecan and AZD7762; n = 10 per group). Mice were followed until death or sacrificed if tumor size reached 2 cm or mice experienced unacceptable toxicities. (A) Kaplan-Meier survival curve following therapy initiation using animal sacrifice as the terminal event. Animals dying of other causes were right-censored from the analysis at the observed time of death and are marked on the survival curves with an X. (B) Median time to animal sacrifice for mice treated in each treatment arm. (C and D) Tumor growth following therapy initiation for individual mice in each treatment group for WU-BC3 and WU-BC4, respectively. (E) Tumor growth curve for individual mice treated with either irinotecan or the combination of irinotecan and AZD7762.