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. 2012 Mar 12;122(4):1519–1528. doi: 10.1172/JCI59743

Figure 5. NF-κB activation accelerated oncogenic Ras–induced pathologies.

Figure 5

Pancreata of acinar-Ras mice 2 weeks after induction of mutant K-RasG12D expression were histologically normal (A, original magnification, ×200). Pancreata of IKKTg mice showed limited inflammation (B, original magnification, ×200). In contrast, expression of both K-RasG12D and IKK2 led to dramatic fibrosis of the pancreas and the development of multiple PanINs (C, original magnification, ×200). The downstream Ras effector p-Erk was dramatically increased in the pancreas of acinar-Ras-IKKTg mice (D, original magnification, ×200) in comparison to mice expressing acinar-Ras (E, ×200) or IKK (F, ×200) alone.