Figure 8. Insulin by itself does not affect glucose uptake in HF slices (A and B) and HF synaptosomes (C and D) of N or AD cases.

Data were derived from the same 8 pairs of cases in which insulin resistance was demonstrated in AD (Figure 5 and Table 2). Shown are (A and C) net [³H] glucose uptake in disintegrations per minute (dpm) and (B and D) percent increase in uptake compared with unstimulated tissue. Whereas 1 and 10 nM insulin had no effect on [³H] glucose uptake in N or AD cases in either tissue preparation, 10 μM glutamate plus 1 μM glycine evoked clear increases in [³H] glucose uptake in both tissue slices and synaptosomes, an effect that was significantly reduced in AD cases. Values are mean ± SEM. *P < 0.0001 vs. N.