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. 2012 Mar 19;122(4):1246–1261. doi: 10.1172/JCI61135

Figure 8. EDN2 increases in glaucoma but not in radiation-treated eyes.

Figure 8

(A) Edn2 expression is upregulated in glaucoma but not in radiation-treated eyes. (B) EDN2+IBA1+ cells are readily detected in retinas of untreated DBA/2J eyes but are rare in radiation-treated eyes. Scale bar: 20 μm. (C) Endothelin-2 is a potent vasoconstrictor, and the ratio of vascular lumen to overall vessel diameter was decreased in DBA/2J eyes with moderate and severe optic nerve damage (MOD+SEV) compared with that in eyes with no glaucoma (NOE, P = 0.001). This ratio was not decreased in Rad-D2 eyes compared with that in NOE eyes (P = 0.78, n > 6 in all groups). Rad-D2 eyes had very little EDN2, and vasoconstriction was prevented to the same degree as in eyes treated with an EDN receptor antagonist (Bosentan, ref. 96, P = 0.90). *q ≤ 0.05.