Table 1.

Summary of SAR Studies Performed on MIPP (Compound 2) and Related Compounds Generated in Schemes 1 and 2.

cmpd #	R1	R2	R3	Ar	Viability (MTT*)	Colony Formation*	Vacuoles?
2 (MIPP)	H	CH3	H		24 ± 3	8 ± 4	yes
9	H	H	H		109 ± 7	76 ± 7	no
10	H	H	H		96 ± 9	53 ± 10	no
11	H	H	H		72 ± 6	71 ± 10	no
12	H	H	H		58 ± 7	22 ± 2	yes
13	CH3O	H	H		58 ± 2	2 ± 1	yes
14		H	H		56 ± 4	8 ± 2	yes
15	OH	H	H		107 ± 22	72 ± 6	no
16	CH3O	H	H		90 ± 8	99 ± 30	no
17	CH3O	H	H		88 ± 8	96 ± 22	no
19 (MOMIPP)	CH3O	CH3	H		12± 2	0	yes
20	CH3O	H	CH3		73 ± 13	52 ± 9	yes
21	OH	CH3	H		101 ± 13	43 ± 17	yes
26		CH3	H		79 ± 2	76 ± 8	no
27		CH3	H		79 ± 9	71 ± 11	no

^*Results are expressed as percent of controls that received vehicle alone (DMSO). Values are the mean ± SD of quadruplicate (MTT) or triplicate (colony formation) determinations.