Table 2. Main effects of NOS3 variants on outcomes, event frequencies and rates, hazard ratios.
| NOS3 −690 C>T | NOS3 −922 A>G | NOS3 glu298asp G>T | |||||||
| Outcome | CC (n = 26,843) | CT+TT (n = 3,426) | P value | AA (n = 15,398) | AG+GG (n = 14,841) | P value | GG (n = 17,606) | GT+TT (n = 12,634) | P value |
| CHD (primary endpoint) | |||||||||
| Event frequency | 2325 | 354 | 1326 | 1350 | 1513 | 1163 | |||
| Event rate* | 18.8 | 22.7 | 18.7 | 19.8 | 18.7 | 20.1 | |||
| Unadjusted HR (95% CI) | 1.00 | 1.20 (1.08–1.34) | 0.001 | 1.00 | 1.06 (0.98–1.14) | 0.15 | 1.00 | 1.07 (0.99–1.16) | 0.07 |
| Adjusted HR† (95% CI) | 1.00 | 1.12 (1.00–1.26) | 0.048 | 1.00 | 0.98 (0.90–1.06) | 0.62 | 1.00 | 1.00 (0.92–1.08) | 0.94 |
| Stroke | |||||||||
| Event frequency | 1218 | 139 | 720 | 638 | 826 | 531 | |||
| Event rate* | 9.8 | 8.7 | 10.1 | 9.2 | 10.1 | 9.0 | |||
| Unadjusted HR (95% CI) | 1.00 | 0.89 (0.75–1.06) | 0.20 | 1.00 | 0.92 (0.82–1.02) | 0.11 | 1.00 | 0.89 (0.80–0.99) | 0.04 |
| Adjusted HR† (95% CI) | 1.00 | 0.96 (0.80–1.15) | 0.63 | 1.00 | 0.97 (0.86–1.09) | 0.58 | 1.00 | 0.95 (0.84–1.07) | 0.38 |
| Heart failure | |||||||||
| Event frequency | 1769 | 243 | 970 | 1041 | 1176 | 833 | |||
| Event rate* | 14.3 | 15.4 | 13.7 | 15.3 | 14.5 | 14.3 | |||
| Unadjusted HR (95% CI) | 1.00 | 1.08 (0.94–1.23) | 0.27 | 1.00 | 1.12 (1.02–1.22) | 0.01 | 1.00 | 0.99 (0.90–1.08) | 0.75 |
| Adjusted HR† (95% CI) | 1.00 | 1.04 (0.90–1.19) | 0.63 | 1.00 | 1.10 (1.00–1.21) | 0.046 | 1.00 | 0.94 (0.85–1.03) | 0.20 |
| All-cause mortality | |||||||||
| Event frequency | 3761 | 498 | 2183 | 2069 | 2527 | 1728 | |||
| Event rate* | 28.6 | 29.7 | 28.9 | 28.5 | 29.3 | 27.9 | |||
| Unadjusted HR (95% CI) | 1.00 | 1.04 (0.95–1.14) | 0.42 | 1.00 | 0.99 (0.93–1.05) | 0.64 | 1.00 | 0.96 (0.90–1.02) | 0.16 |
| Adjusted HR† (95% CI) | 1.00 | 1.05 (0.95–1.15) | 0.37 | 1.00 | 0.99 (0.93–1.05) | 0.72 | 1.00 | 0.97 (0.91–1.03) | 0.32 |
| End-stage renal disease | |||||||||
| Event frequency | 366 | 30 | 214 | 181 | 264 | 131 | |||
| Event rate* | 2.9 | 1.9 | 2.9 | 2.6 | 3.2 | 2.2 | |||
| Unadjusted HR (95% CI) | 1.00 | 0.64 (0.44–0.93) | 0.02 | 1.00 | 0.88 (0.72–1.07) | 0.19 | 1.00 | 0.69 (0.56–0.85) | 0.0005 |
| Adjusted HR† (95% CI) | 1.00 | 0.84 (0.57–1.23) | 0.36 | 1.00 | 1.09 (0.98–1.35) | 0.44 | 1.00 | 0.84 (0.67–1.06) | 0.14 |
*per 1000 person-year.
†
adjusted for treatment, age, sex, race, Hispanic status, baseline BMI, diabetes status, baseline total cholesterol, smoking status, baseline systolic and diastolic blood pressures. CHD, coronary heart disease (including fatal CHD and nonfatal myocardial infarction); CI, confidence interval; HR, hazard ratio.