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. 2001 Apr 24;98(9):4961–4965. doi: 10.1073/pnas.091100698

Figure 1.

Figure 1

Sequences of nucleic acids and proteins. (A) Nucleic acid sequences of the RNA aptamers M5, M56, M69, TR-M69, and TR-ML1, respectively. Black, initial random sequence; blue, 5′ and 3′ terminal regions for primer annealing; yellow, 5′ and 3′ stem-loop sequences of the TR-expression cassette. (B) Secondary structure prediction of M69 proposed by the program mfold (26). Blue, constant 5′ and 3′ terminal regions of the RNA aptamer. (C) Amino acid sequence of cytohesin 1. Red, C1-Sec7 domain, responsible for M69 binding; green, amino acid E157 residue critical for ARF-GEF activity mutated in cytohesin 1(E157K).