Table 2. Percentage of different Treg subsets of the total Treg pool obtained from healthy non-transplanted volunteers and kidney transplant patients in the presence or absence of BPR.
Time after Tx [days] | n | DR−CD45RA+[% Tregs] | DR−CD45RA−[% Tregs] | DRlow+ CD45RA−[% Tregs] | DRhigh+ CD45RA−[% Tregs] | HLA-DR MFI | |
Controls | 20 | 34 (17–61) | 33 (19–45) | 25 (14–33) | 7.5 (4.5–20.1) | 10470 (7607–15090) | |
No BPR | 0–30 | 36 | 20 (5–50) | 37 (21–59) | 34 (14–53) | 2.8 (0.5–9.6) | 4604 (2112–9076) |
31–1000 | 48 | 35 (13–62) | 42 (27–65) | 16 (5–29) | 2.5 (0.4–7.8) | 7431 (2782–16440) | |
>1000 | 35 | 24 (7–59) | 33 (22–57) | 28 (7–47) | 8.4 (2.1–24.8) | 11102 (7219–21025) | |
BPR | 0–30 | 5 | 16 (10–30) | 35 (30–45) | 37 (30–47) | 3.6 (2.0–4.3) | 4058 (4002–4817) |
31–1000 | 15 | 28 (12–47)* | 51 (34–62)* | 16 (9–27) | 1.7 (1.0–2.8)* | 5151 (3230–6401)* | |
>1000 | 17 | 21 (6–41) | 46 (32–60)*** | 26 (14–41) | 4.7 (2.2–8.1)*** | 6843 (5312–9105)*** |
: p<0.05; no BPR versus BPR.
: p<0.001; no BPR versus BPR.