Table 1. Parameters for lipid related products in liver and plasma.
Wt-tp mice | Cd36−/−-tp mice | Msr1 −/−-tp mice | |
Liver | |||
Triglycerides (µg) | 0.38 (±0.02) | 0.40 (±0.03) | 0.47 (±0.02)* |
Free fatty acids (µg) | 0.17 (±0.003) | 0.19 (±0.006) | 0.20 (±0.01)* |
Cholesterol (µg) | 0.08 (±0.0038) | 0.10 (±0.0062) | 0.11 (±0.0071)** |
Lathosterol (ng/mg liver) | 21.8 (±1.76) | 19.71 (±2.44) | 19.10 (±2.55) |
Desmosterol (ng/mg liver) | 16.11 (±1.06) | 14.44 (±0.85) | 12.62 (±0.92)* |
Cholestanol (ng/mg liver) | 93.03 (±8.42) | 97.33 (±6.38) | 126.7 (±11.22)*, # |
Cholesterol esters (µg/mg liver) | 14.37 (±1.58) | 21.2 (±1.88)* | 20.99 (±1.27)** |
Free cholesterol (µg/mg liver) | 8.63 (±0.28) | 9.00 (±0.23) | 8.16 (±0.36) |
Plasma | |||
Triglycerides (mM) | 1.49 (±0.16) | 1.29 (±0.14) | 1.27 (±0.18) |
Free fatty acids (mM) | 0.58 (±0.04) | 0.59 (±0.06) | 0.45 (±0.03) |
Cholesterol (mg/dl) | 1052 (±113.1) | 1210 (±37.76) | 1097 (±69.45) |
Lathosterol (mg/dl) | 0.31 (±0.03) | 0.24 (±0.04) | 0.17 (±0.03)** |
Desmosterol (mg/dl) | 0.77 (±0.06) | 0.77 (±0.08) | 0.52 (±0.06)*, # |
Cholestanol (mg/dl) | 3.03 (±0.31) | 4.34 (±0.13)** | 4.60 (±0.14)** |
7α-OH cholesterol (ng/ml) | 1.50 (±0.13) | 1.02 (±0.13)* | 0.92 (±0.03)** |
24-OH cholesterol (ng/ml) | 448.8 (±46.85) | 506.5 (±28.77) | 505.6 (±41.62) |
27-OH cholesterol (ng/ml) | 504 (±59.81) | 504.8 (±42.63) | 455 (±46.12) |
MDA-LDL IgM (RLU) | 86348 (±4857) | 89405 (±6189) | 113896 (±2889)***,## |
CuOx-LDL IgM (RLU) | 31987 (±6331) | 62903 (±11844)* | 102371 (±6341)***,## |
T15id+ (IgM) (RLU) | 3726 (±395.2) | 9000 (±1815)* | 19079 (±3412)**, # |
ALT (U/l) | 61 (±9.35) | 58.43 (±3.40) | 65.5 (±3.53) |
AST (U/l) | 129.5 (±13.77) | 79 (±14.3)* | 84 (±6.52)* |
AST/ALT | 2.25 (±0.38) | 1.52 (±0.15) | 1.28 (±0.07)* |
Significantly different from Wt-tp group. *, ** and *** indicate p<0.05, 0.01 and 0.001, respectively. RLU: Relative light unit.
Significantly difference between Cd36−/−-tp and Msr1−/−-tp mice. # and ## indicate p<0.05 and 0.01 respectively.