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. 2012 Mar 28;7(3):e34316. doi: 10.1371/journal.pone.0034316

Figure 6. Presence of treats affects orexin activation, which is associated with motivational behaviour.

Figure 6

(a) The activation of orexin cells in adult re-injured animals with a ‘pain history’ (IN+IN) is dictated by the presence or absence of food treats in the central bowl of the NIH arena. When treats are present in this group, orexin cell activation increases to 27.2±4.1% compared to when treats are absent (14.8±3.1%) and at baseline (15.5±2.6%). ‘Baseline’ data refers to animals with a history of incision but no adult re-injury (IN), tested in the presence of treats. *p<0.05; one-way ANOVA with Bonferroni's post-tests. (b) There is a strong correlation within individual animals (r = −0.86, p = 0.013) between the percentage of orexin cells co-expressing c-Fos and the number of rears performed by the IN+IN group during testing in the NIH arena.