Table 2. NIH arena results for all four experimental groups.
| Outcome Measure | Treatment Group | |||
| AN (n = 13) | IN (n = 19) | AN+IN (n = 14) | IN+IN (n = 14) | |
| Faeces | 2.15±0.55 | 1.95±0.35 | 3.36±0.70 | 3.5±0.50 # |
| Urine | 1.92±0.37 | 2.26±0.48 | 3.07±0.45 | 2.74±0.46 |
| Rears (5–10 mins) | 19.15±2.32 | 17.74±1.51 | 9.50±1.41 *** | 8.14±0.17 ### |
| CZ entries (5–10 mins) | 6.77±0.93 | 7.68±0.74 | 7.50±0.51 | 6.93±0.68 |
| CZ time (%)(5–10 mins) | 22.47±6.69 | 23.69±4.77 | 43.69±5.89 * | 43.49±5.48 # |
| Time to 1st treat (s) | 479.0±51.54 | 374.5±26.53 | 378.5±24.48 | 416.5±46.90 |
| Number eaten (5–10 mins) | 5.0±1.17 | 6.42±0.73 | 8.1±0.66 | 7.21±0.91 |
| Non-eaters (p-value from expected 100% baseline) | 3/13 (0.22) | 7/19 (0.008) ▴ | 2/14 (0.48) | 2/14 (0.48) |
AN = repeated neonatal anesthesia. IN = repeated neonatal skin incision. AN+IN = repeated neonatal anesthesia plus adult incision. IN+IN = repeated neonatal skin incision plus adult incision. Results are mean ± SEM. Significant results are highlighted in bold.
*p<0.05 and
***p<0.001, compared to AN group.
#
p<0.05,
###
p<0.001, compared to IN group; two-way ANOVA for each outcome measure with Bonferroni's Multiple Comparison Tests.
▴
compared to an expected baseline of 100% eaters; Fisher's Exact test.