Table 2. Discovery analysis: SNP association with ALS outcome using GENEVA controls only.

						Minor allele frequency
Chr	SNP	Pos (build 36)	Closest gene (distance)	Odds ratio (95% CI)	p	Cases	Controls
22	rs5762919	27693344	ZNRF3	0.3 (0.2, 0.5)	1.7E-07	0.04	0.10
4	rs1425419	124785414	LOC285419 (8 kb)	2.1 (1.5, 2.8)	1.9E-06	0.19	0.11
19	rs12327672	43742319	RYR1	0.4 (0.2, 0.5)	2.5E-06	0.04	0.11
7	rs2867161	67274777	STAG3L4 (851 kb)	0.4 (0.3, 0.6)	3.7E-06	0.06	0.13
7	rs17145184	67278550	STAG3L4 (855 kb)	0.4 (0.3, 0.6)	5.4E-06	0.07	0.13
7	rs7777387	22086962	RAPGEF5 (37 kb)	0.3 (0.2, 0.5)	5.6E-06	0.02	0.07
4	rs6816453	60844956	none within 1 Mb	0.5 (0.4, 0.7)	6.4E-06	0.13	0.23
10	rs7912496	87832985	GRID1	0.5 (0.4, 0.7)	7.6E-06	0.11	0.19
9	rs1796991	74507694	TMC1	0.5 (0.4, 0.7)	8.0E-06	0.14	0.23
4	rs7689003	44820582	GNPDA2 (397 kb)	0.6 (0.5, 0.8)	1.5E-05	0.27	0.38
15	rs11071021	52143583	UNC13C	0.6 (0.5, 0.8)	1.5E-05	0.36	0.47
18	rs17783459	40583074	SETBP1	2.1 (1.5, 3.0)	1.5E-05	0.15	0.07
5	rs4868146	171514050	STK10	0.6 (0.5, 0.8)	1.5E-05	0.32	0.42
4	rs4470701	52798649	SPATA18 (140 kb)	0.6 (0.5, 0.8)	1.7E-05	0.25	0.35
14	rs1950202	53909646	CDKN3 (24 kb)	0.6 (0.5, 0.8)	1.8E-05	0.25	0.35
4	rs10050211	60639119	none within 1 Mb	0.5 (0.3, 0.7)	1.9E-05	0.07	0.13
15	rs11071022	52149769	UNC13C	0.6 (0.5, 0.8)	1.9E-05	0.35	0.46
2	rs4972990	231987255	B3GNT7 (13 kb)	0.6 (0.5, 0.8)	2.1E-05	0.36	0.47
8	rs11204102	20137423	LZTS1 (11 kb)	1.7 (1.3, 2.1)	2.2E-05	0.36	0.25
15	rs1563755	27660863	FAM189A1 (11 kb)	0.6 (0.5, 0.8)	2.3E-05	0.28	0.38
15	rs8031323	27662042	FAM189A1 (12 kb)	0.6 (0.5, 0.8)	2.3E-05	0.28	0.38
2	rs2034413	231996393	B3GNT7 (22 kb)	0.6 (0.5, 0.8)	2.4E-05	0.29	0.39
2	rs2034412	231996305	B3GNT7 (22 kb)	0.6 (0.5, 0.8)	2.5E-05	0.29	0.39
2	rs16862162	174441451	SP3 (38 kb)	0.6 (0.5, 0.7)	2.6E-05	0.17	0.27
18	rs9959302	34316183	LOC647946 (725 kb)	0.6 (0.5, 0.8)	2.7E-05	0.31	0.41