Table 6. Replication and pooled analysis: SNP association with ALS survival.

				Discovery analysis		Replication analysis		Pooled analysis
Chr	SNP	pos (build 36)	Closest gene (distance)	Hazard ratio (95% CI)	P	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p
4	rs6840169	83637534	TMEM150C	1.5 (1.2, 1.7)	7.8E-06	1.2 (0.8, 1.9)	0.40	1.4 (1.2, 1.6)	3.9E-05
6	rs564053	94874715	TSG1 (332 kb)	1.4 (1.2, 1.7)	9.6E-06	1.1 (0.7, 1.6)	0.62	1.4 (1.2, 1.6)	5.5E-05
15	rs873961	59135496	RORA	0.7 (0.6, 0.8)	1.4E-05	1.2 (0.9, 1.6)	0.31	0.8 (0.7, 0.9)	7.2E-05
15	rs11632352	59145158	RORA	0.7 (0.6, 0.9)	3.2E-05	1.1 (0.8, 1.5)	0.63	0.8 (0.7, 0.9)	7.5E-05
6	rs7764218	162854134	PARK2	0.5 (0.4, 0.7)	8.6E-06	1.1 (0.7, 1.8)	0.65	0.6 (0.5, 0.8)	1.5E-04
6	rs7757630	162860228	PARK2	0.5 (0.4, 0.7)	7.9E-06	1.1 (0.7, 1.7)	0.72	0.6 (0.5, 0.8)	1.5E-04
15	rs8037669	59137212	RORA	0.7 (0.6, 0.8)	1.7E-05	1.3 (0.9, 1.9)	0.11	0.8 (0.7, 0.9)	1.6E-04
6	rs7740421	162890461	PARK2	0.5 (0.4, 0.7)	7.4E-06	1.2 (0.7, 2)	0.56	0.6 (0.5, 0.8)	2.5E-04
20	rs6027005	57632613	PHACTR3	1.7 (1.3, 2.3)	2.0E-04	0.8 (0.2, 3.3)	0.75	1.7 (1.3, 2.2)	4.1E-04
6	rs6904956	162865529	PARK2	0.5 (0.4, 0.7)	9.5E-06	0.9 (0.7, 1.4)	0.76	0.7 (0.5, 0.8)	5.1E-04