Figure 9. NO is partially involved in CpG-B-induced death of R. australis-infected mice.

WT and iNOS^−/− mice (8 mice per group) were injected i.v. with different doses of R. australis (A). At day 2 after infection with 5×10⁵ pfu of R. australis, 50 µg of ODN control (ODN 1826 control) and CpG-B (ODN 1826) per mouse were injected i.v. into WT and iNOS^−/− mice (8 mice per group), respectively (B). Mouse survival was monitored for 14 days.