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50 µg of ODN control (ODN 1826 control) and CpG-B (ODN 1826) per mouse were injected i.v. into WT and IDO−/− (A) or iNOS−/− mice (B) (5 mice per group) respectively. Two days later, those mice were infected with an ordinarily lethal dose of R. australis (2×106 pfu). Mouse survival was monitored for 14 days.
