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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: J Mol Model. 2011 Nov 30;18(6):2831–2843. doi: 10.1007/s00894-011-1307-x

Table 2.

Structure and activity of 2-(5-alkoxybenzimidazol-2-ylthio)-N-phenylacetamide derivatives in human neutrophils and FPR1/FPR2-transfected HL-60 cells

graphic file with name nihms344564u2.jpg
Compound R1 R2 R3 Ca2+ mobilization EC50 (μM) and efficacy (%)a
FPR1 FPR2 Neutrophils
AG-11/22 graphic file with name nihms344564t1.jpg H OCH2CH3 6.9 (50) 14.3 (35) 3.9 (60)
AG-11/23 graphic file with name nihms344564t2.jpg H OCH3 2.2 (70) N.A. 2.6 (80)
AG-11/24 graphic file with name nihms344564t3.jpg H OCH2CH3 14.2 (65) 3.7 (40) 5.6 (75)
AG-11/25 graphic file with name nihms344564t4.jpg H OCH3 2.1 (110) 10.4 (70) 1.5 (105)
AG-11/26 graphic file with name nihms344564t5.jpg CH3 OCH3 7.5 (90) 11.0 (45) 17.8 (75)
a

See legend for Table 1