Table 3.
Risk of pancreatic cancer with gabapentin exposure in the GPRD
| Exposure Model | Without 2 year lag | With 2 year lag | ||
|---|---|---|---|---|
| Unadjusted OR (95% CI) | Adjusted OR (95% CI)1 | Unadjusted OR (95% CI) | Adjusted OR (95% CI)1 | |
| Gabapentin (Ever vs Never) | 2.04 (1.51, 2.75) | 1.82 (1.34, 2.46) | 1.52 (0.98, 2.36) | 1.33 (0.85, 2.08) |
| Gabapentin Prescriptions 2,3 | ||||
| Tertile1 vs Never | 2.82 (1.86, 4.28) | 2.53 (1.66, 3.85) | 2.75 (1.51, 5.03) | 2.44 (1.32, 4.49) |
| Tertile2 vs Never | 1.80 (0.97, 3.36) | 1.65 (0.87, 3.11) | 0.55 (0.17, 1.78) | 0.48 (0.15, 1.57) |
| Tertile3 vs Never | 1.35 (0.76, 2.42) | 1.17 (0.65, 2.11) | 1.31 (0.58, 2.97) | 1.11 (0.48, 2.57) |
| Duration of exposure (mo) 4,5 | ||||
| Tertile1 vs Never | 3.15 (2.04, 4.86) | 2.88 (1.85, 4.46) | 2.75 (1.47, 5.13) | 2.45 (1.31, 4.62) |
| Tertile2 vs Never | 1.68 (0.94, 2.99) | 1.50 (0.83, 2.69) | 0.82 (0.29, 2.28) | 0.72 (0.26, 2.01) |
| Tertile3 vs Never | 1.34 (0.75, 2.39) | 1.15 (0.64, 2.07) | 1.11 (0.49, 2.51) | 0.94 (0.41, 2.15) |
| Cumulative Exposure (g) 6,77 | ||||
| Tertile1 vs Never | 2.90 (1.88, 4.47) | 2.65 (1.71, 4.11) | 2.19 (1.12, 4.25) | 1.95 (0.99, 3.81) |
| Tertile2 vs Never | 1.87 (1.05, 3.32) | 1.64 (0.92, 2.95) | 1.42 (0.64, 3.16) | 1.21 (0.54, 2.72) |
| Tertile3 vs Never | 1.34 (0.75, 2.39) | 1.15 (0.64, 2.08) | 1.01 (0.42, 2.41) | 0.87 (0.36, 2.12) |
OR, odds ratio; CI, confidence interval; vs, versus; mo, months; g, grams; GPRD, General Practice Research Database.
Adjusted for smoking, body mass index, diabetes, chronic pancreatitis, neuropathic pain, epilepsy
The tertiles for number of prescriptions in the analysis without 2 year lag are: Tertile 1 (1–2). Tertile 2 (3–8). Tertile3 (9–218).
The tertiles for number of prescriptions in the analysis with 2 year lag are: Tertile 1 (1–2). Tertile 2 (3–10). Tertile 3(11–191).
The tertiles for cumulative duration in the analysis without 2 year lag are: Tertile 1 (0.01 – 1.55 mo). Tertile 2 (1.56 – 6.44 mo). Tertile 3 (6.45 – 78.36 mo).
The tertiles for cumulative duration in the analysis with 2 year lag are: Tertile 1 (0.01 – 1.78 mo). Tertile 2 (1.79 – 7.20 mo). Tertile 3 (7.21 – 64.13 mo)
The tertiles for cumulative dose in the analysis without 2 year laq are: Tertile 1 (0.01 – 33.6 g). Tertile 2 (33.7 – 185.0 g). Tertile 3 (185.1 – 7500.2 g).
The tertiles for cumulative dose in the analysis with 2 year lag are: Tertile 1 (0.01 – 39.0 g) Tertile 2 (39.1 – 210.0 g). Tertile 3 (210.1 – 5623.8 g).