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. 2012 Mar 1;106(7):1274–1279. doi: 10.1038/bjc.2012.69

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Copyright © 2012 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

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Kaplan–Meier survival curves demonstrating the survival of the patients divided in three groups by virtue of the chemotherapeutic drug used: Group 1 received Mitomycin (n=98, median survival 24 months). Group 2 treated with a Mitomycin-Gemcitabine combination (n=49, median survival 23 months). Group 3 treated with a Mitomycin-Irinotecan combination (n=77, median survival 22.5 months). Log-rank test results showed a statistically significant difference between the three groups of patients (P<0.01).