Table 4. Geometric means (s.d.) for fasting C-peptide (ng ml–1) for 1862 women by deciles (D) of magnesium intake in the Nurses’ Health Study.
|
Magnesium deciles
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Intakes | D1 | D2 | D3 | D4 | D5 | D6 | D7 | D8 | D9 | D10 | P for trend |
| Total magnesiuma (mg per day) | |||||||||||
| Medians | 211 | 240 | 258 | 272 | 287 | 304 | 322 | 344 | 373 | 434 | |
| No. of controls | 197 | 187 | 188 | 184 | 180 | 187 | 186 | 173 | 199 | 183 | |
| Model 1b | 1.51 (1.38, 1.66) | 1.46 (1.34, 1.58) | 1.34 (1.22, 1.47) | 1.33 (1.21, 1.48) | 1.41 (1.28, 1.56) | 1.35 (1.24, 1.47) | 1.41 (1.29, 1.53) | 1.35 (1.24, 1.48) | 1.30 (1.21, 1.41) | 1.26 (1.17, 1.36) | 0.002 |
| Model 2c | 1.65 (1.50, 1.81) | 1.63 (1.50, 1.78) | 1.41 (1.28, 1.55) | 1.53 (1.38, 1.70) | 1.58 (1.43, 1.74) | 1.54 (1.41, 1.69) | 1.62 (1.47, 1.77) | 1.57 (1.43, 1.72) | 1.53 (1.41, 1.67) | 1.52 (1.40, 1.66) | 0.39 |
| Model 3d | 1.61 (1.45, 1.78) | 1.59 (1.45, 1.74) | 1.40 (1.27, 1.55) | 1.49 (1.33, 1.67) | 1.55 (1.41, 1.71) | 1.51 (1.38, 1.66) | 1.57 (1.42, 1.73) | 1.57 (1.42, 1.73) | 1.51 (1.38, 1.65) | 1.50 (1.36, 1.66) | 0.61 |
| Dietary magnesiuma (mg per day) | |||||||||||
| Medians | 208 | 237 | 252 | 2656 | 278 | 294 | 308 | 326 | 347 | 387 | |
| No. of controls | 198 | 183 | 190 | 177 | 201 | 193 | 171 | 188 | 174 | 189 | |
| Model 1b | 1.52 (1.40, 1.65) | 1.42 (1.29, 1.55) | 1.44 (1.33, 1.56) | 1.33 (1.20, 1.48) | 1.41 (1.30, 1.53) | 1.37 (1.25, 1.49) | 1.29 (1.18, 1.41) | 1.41 (1.30, 1.53) | 1.26 (1.15, 1.37) | 1.27 (1.18, 1.38) | 0.0007 |
| Model 2c | 1.66 (1.53, 1.80) | 1.60 (1.45, 1.76) | 1.54 (1.41, 1.68) | 1.46 (1.31, 1.63) | 1.62 (1.49, 1.76) | 1.56 (1.42, 1.71) | 1.48 (1.35, 1.62) | 1.63 (1.49, 1.79) | 1.47 (1.34, 1.61) | 1.54 (1.41, 1.68) | 0.21 |
| Model 3d | 1.63 (1.49, 1.79) | 1.56 (1.41, 1.72) | 1.52 (1.39, 1.68) | 1.44 (1.29, 1.61) | 1.59 (1.46, 1.74) | 1.53 (1.39, 1.70) | 1.43 (1.30, 1.58) | 1.58 (1.43, 1.75) | 1.44 (1.31, 1.60) | 1.50 (1.36, 1.66) | 0.24 |
Abbreviation: MET=metabolic equivalent.
The magnesium intakes were based on 1990 data from the Nurses’ Health Study. Geometric mean values were centred at age 60 years.
Model 1 was adjusted for age at blood draw (in months).
Model 2 was adjusted for age at blood draw (in months), smoking before age 30 (0, 1–4, 5–10, or >10 pack-years), history of colorectal cancer in a parent or sibling (yes, no), history of endoscopy (yes, no), regular aspirin use (yes, no), body mass index (<25, 25–<30, ⩾30 kg m–2), physical activity (<3, 3–<27, ⩾27 MET-hours per week), postmenopausal hormone use (premenopausal, never, past, or current user).
Model 3 was further adjusted for consumption of processed meat (quintiles), consumption of beef, pork, or lamb as a main dish (quintiles), alcohol consumption (0–<5, 5–<10, 10–<15, or ⩾15 g per day), energy-adjusted total calcium intake (quintiles), total folate (quintiles), total vitamin D intake (quintiles), and total energy intake (quintiles).