Table 2.

Time course of thermal antihyperalgesic effects after intrathecal injection of morphine, citalopram, paroxetine, and combinations

Data are means ± SDs from eight rats per group. C, citalopram 100 µg; P, paroxetine 100 µg; m, morphine 0.3 µg; M, morphine 1 µg; T, methysergide 100 µg pretreatment; N, naloxone 20 µg pretreatment; mC, mP, MC, MP, TM, NC, and NP, the antihyperalgesic interaction of both drugs; NMC and NMP, pretreatment of naloxone 20 µg before co-administration of both drugs; TMC and TMP, pretreatment of methysergide 100 µg before co-administration of both drugs. ^*< 0.05 vs m; ^†< 0.05 vs M; ^‡< 0.05 vs MC; ^§< 0.05 vs MP; ^∥< 0.05 vs C; ^¶< 0.05 vs P.