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. Author manuscript; available in PMC: 2013 Mar 16.
Published in final edited form as: Circ Res. 2012 Feb 16;110(6):841–850. doi: 10.1161/CIRCRESAHA.111.258251

Figure 5.

Figure 5

Myofilament Ca2+ responsiveness in skinned fiber bundles isolated from DOCA-salt and sham hearts with and without ranolazine. A-D: The mean steady-state isometric tension of skinned fiber bundles is plotted as a function of pCa. DOCA-salt fibers demonstrate a significant (p<0.05) increase in maximum tension (44.51 ± 0.55 mN/mm2; n = 6) compared to shams (39.7 ± 0.79 mN/mm2; n = 6) and DOCA-salt fibers treated with ranolazine (36.03 ± 1.50 mN/mm2). DOCA-salt fibers demonstrate a significant (p<0.05) increase in mean Ca2+ sensitivity (pCa50 = 6.09 ± 0.01; n = 6) compared to shams (pCa50 = 6.02 ± 0.01; n = 6). Treatment with ranolazine normalized these changes. E: pCa-tension relations normalized to maximum tension. DOCA-salt fibers (pCa50 = 6.1 ± 0.02; Hill n = 3.42 ± 0.30) demonstrate a significant increase in mean Ca2+ sensitivity (n=6, *p < 0.05) as compared to shams without DOCA treatment (pCa50 = 6.0 ± 0.01; Hill n = 3.80 ± 0.61) shams with DOCA treatment (pCa50 = 6.0 ± 0.01; Hill n = 3.91 ± 0.50) and fibers from DOCA mice and treated with ranalozine (pCa50 = 6.0 ± 0.03; Hill n = 3.71 ± 1.0).