Table 1B.

Effect of ranolazine on hemodynamics

	Sham	Sham + ranolazine	DOCA-salt	DOCA-salt + ranolazine
SBP(mmHg)	88 ±3*†	93 ±3*	109 ±7	102 ±3
DBP(mm Hg)	52 ±5*†	58 ±2*†	78 ±4	73 ±2
HR(bpm)	618 ± 24	620 ±5	589 ± 16	588 ± 16
LVESP (mm Hg)	83 ±2*	85 ±3*	108 ±7	98 ±3
LVEDP(mmHg)	3.2 ±0.3*	4.2 ±0.5	5.1 ±0.9	3.5 ±0.4*
EF (%)	71 ±6	73 ±5	67 ±6	67 ±4
EDPVR (mm Hg/μL)	0.16 ±0.01*	0.18 ±0.01*	0.23 ± 0.02	0.17 ±0.01*
ESPVR (mm Hg/μL)	3 ±0.6	3.9 ±0.5	4.7 ±0.8	4.1 ±0.2
dP/dt min (mm Hg/sec)	−10,420 ± 594	−10,083 ± 685	−12,181 ±641	−12,211 ±792
dP/dt max (mm Hg/sec)	12,818 ± 490	12,032± 787	13,585 ± 832	12,495 ± 555

Data are means ± SEM. SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; LVESP, left ventricular end systolic pressure; LVEDP, left ventricular end diastolic pressure; EF, ejection fraction; EDPVR, end diastolic pressure volume relationship. ESPVR, end systolic pressure volume relationship. n=8,

^*p < 0.05 vs. DOCA-salt.

^†p < 0.05 vs. DOCA-salt + ranolazine.