Table 1.

Analysis of plasma markers after long-term (12 mon) ethanol (EtOH) treatment

Plasma	Control	EtOH
EtOH [mM=‰=mg/dl]	below DL	12.5 ± 5.2=0.7 ± 0.3=57.7 ± 23.3⁎
Cholesterol [mg/ml]	0.7 ± 0.1	0.5 ± 0.1 ns
tPA [ng/ml]	10.9 ± 1.4	13.7 ± 3.0 ns
Aβ(1–40) [pM]	38.7 ± 5.9	37.6 ± 8.9 ns
Aβ(1–42) [pM]	3.7 ± 0.3	4.8 ± 0.8 ns
IL-1β [pg/ml]	9.7 ± 7.7	10.1 ± 4.0 ns
MIP-2 [pg/ml]	3.8 ± 1.7	4.8 ± 2.7 ns
TNF-α [pg/ml]	29.3 ± 19.5	19.4 ± 13.0 ns
MCP-1 [ng/ml]	3.6 ± 0.5	3.0 ± 0.3 ns

Sprague–Dawley rats were administered normal water (controls) or 20% EtOH-enriched water for 12 mon. Blood was collected and plasma samples were analyzed with the ethanol detection kit for EtOH levels, cholesterol by HPLC-UV detection, and ELISAs for interleukin 1-beta (IL-1β), monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2), tumor necrosis factor-alpha (TNF-α), tissue plasminogen activator (tPA), beta amyloid_(1–40) (Aβ_(1–40)), beta-amyloid_(1–42) (Aβ_(1–42)). Values are given as mean±SEM in [pg/ml, ng/ml, pM, mg/dl, or %]. Statistical analysis was performed with a one-way ANOVA with a Fisher LSD post hoc test (n=6 animals per group; tPA, n=3). ns, not significant; below DL, below detection limit,

^⁎P<0.001.