Table 2.

Effect of the solvent on the reaction^a

Entry	Solvent	Yield (%)	Snyder polarity indexb
1	CHCl3	62	4.1
2	CH2Cl2	58	3.1
3	DCE	46	3.5
4	EtOAc	16	4.4
5	DMF	0	6.4
6	NMP	0	6.7
7	MeCN	10	5.8
8	Et2O	54	2.8
9	CPMEc	38	Not available
10	THF	21	4.0
11	1,4-Dioxane	0	4.8
12	Toluene	66	2.4

^aMonitored by TLC, product isolated by radial-band chromatography and the structure confirmed by NMR spectroscopy.

^bPolarity is indicated by the Snyder Polarity Index.²⁶

^cCMPE-cyclopentyl methyl ether.