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. 2012 Mar 29;6:7. doi: 10.3389/fnbeh.2012.00007

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Copyright © 2012 Radley.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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Two disynaptic pathways from medial prefrontal cortex (mPFC) are proposed to account for the differential modulation of emotional stress-induced HPA output. Whereas evidence highlighted in the text [see also, Radley et al. (2009)] supports GABAergic neurons in the anterior bed nuclei of the stria terminalis (aBST) as interceding for the HPA-inhibitory influences of prelimbic cortex (PL; red lines), the pathway from infralimbic cortex (IL) is suggested, and remains to be verified with functional studies. ac, anterior commissure; ACTH, adrenocorticotropic hormone; Ant. Pit., anterior pituitary gland; cc, corpus callosum; CRF, corticotropin-releasing factor; ot, optic tract; PVH, paraventricular nucleus of the hypothalamus.