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. 2012 Mar 29;6:7. doi: 10.3389/fnbeh.2012.00007

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Copyright © 2012 Radley.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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Summary of effects of chronic stress on structural plasticity in mPFC pyramidal neurons. In these studies (Radley et al., 2004, 2006b, 2008a), high resolution analyses were performed in digitally reconstructed dendritic segments from fluorescent dye-injected pyramidal neurons in dorsal anterior cingulate (ACd) and prelimbic (PL) areas. An atlas plate (lower left) depicts the approximate region within mPFC that neurons were filled for morphologic analyses. Distance in millimeters relative to bregma is indicated. Arrows highlight the fact that dendritic atrophy and spine/excitatory synapse loss is most prominent on distal apical dendrites (right). Spine morphologic analyses reveal fewer spines with mature (stubby, mushroom-shaped), and a greater number with immature (long and thin) phenotype.