Fig. 6.
Estimation of the release time course using the binomial correction over a wide range of biologically realistic conditions. (A) Sample histograms for a simulated experiment with 500 stimulations, for a synapse with parameters as in Fig. 2, but having non-uniform P with a coefficient of variation (CVP) of 0.6. (B–D) Results of simulations with large number of trials for synapses with a failure rate of 20% are plotted as the error in estimating the FWHM for various problems, described in detail in Section 3.3.3 (note the different scales on the X axes). (B) Effect of non-uniform P, expressed using CVP. (C) Effect of wrongly estimating the number of vesicles; EN, relative error in N. (D) Effect of axonal transmission failures; nSM, fraction of postsynaptic successes missed.