Table 1.
Demographics of Subjects
| Met-COMT, Placebo | Val-COMT, Placebo | Met-COMT, Placebo | Met-COMT, Placebo | ANOVA, p | |
|---|---|---|---|---|---|
| Numbera | 18 | 16 | 16 | 17 | |
| Ethnicityb | 17C, 1I | 12C, 2I, 1Ch, 1A | 16C | 14C, 2I, 1Ch | |
| Age (Years) | 22.6 (3.2) | 24.0 (5.1) | 24.4 (9.0) | 23.9 (3.9) | .80 |
| NART | 118 (4) | 117 (5) | 115 (5) | 116 (6) | .23 |
| Alcohol (Units/Week) | 10 (7) | 8 (5) | 7 (5) | 8 (8) | .59 |
| Cigarettes/Day | 0 (0) | .4 (1.3) | .4 (1.5) | .2 (.7) | .60 |
| BDI | 3.9 (5.3) | 3.5 (3.3) | 3.7 (3.7) | 3.1 (2.9) | .89 |
| STAI | 32 (8) | 39 (7) | 33 (10) | 37 (8) | .09 |
Values are mean (SD).
ANOVA, analysis of variance; BDI, Beck Depression Inventory; COMT, catechol-O-methyltransferase Val158Met genotype; NART, National Adult Reading Test; STAI, Spielberger Trait Anxiety Inventory.
a
Seven subjects completed the gambling task but not the N-back. Final sample size for the N-back task was as follows: n = 15 (Met-COMT placebo), 15 (Val-COMT placebo), 16 (Met-COMT tolcapone), and 14 (Val-COMT tolcapone). The demographics of the 60 who completed the N-back were virtually identical to those given here for the whole sample.
b
C, Caucasian; Ch, Chinese; I, Indian; A, African Caribbean.