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. 2012 Feb 14;22(2):459–467. doi: 10.1016/j.devcel.2011.12.010

Figure 4.

Figure 4

A Model Representing the Fine Balance of ETS Factor Binding and Their Effects on Shh Expression

(A) Representation of the expression patterns of the activating ETS factors (ETS1 and GABPα) and the repressing ETS factors (ETV4 and ETV5).

(B) A summary diagram of how four of the transgenic constructs are proposed to interact with the available ETS factors in the limb, with the expression pattern observed for each construct shown in the middle. The change in the balance between activating and repressing activity represented on the right shows the relative balance in the anterior and posterior margins of the limb. The size of the lettering represents the relative amounts of the activating and repressing activities.