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. 2012 Mar 29;3:46. doi: 10.3389/fphar.2012.00046

Figure 3.

Figure 3

Light (LM) and electronmicrographs (EM) of early developing brain blood vessels and choroid plexus, illustrating functional effectiveness of tight junctions. (A) (LM) and (B) (EM) of newborn opossum injected intraperitoneally (i.p.) with 3 kDa biotin dextran. Reaction product confined to vessel lumen (A) not passing through tight junctions [(B), arrowhead]. (C) Newborn opossum choroid plexus injected i.p. with 3 kDa biotin dextran which does not pass through tight junction (arrowhead). (D) E15 rat, tracer injected into lateral ventricle. Choroid plexus tight junctions (arrowhead): no passage of tracer between cells. Images: (A,B) from Ek et al. (2006); (C,D) from Ek et al. (2003). Scale bars: (A), 25 μm; (B), 200 nm; (C), 100 nm; (D), 300 nm.